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KMID : 1007320110170010027
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Journal of the Korean Society of Menopause
2011 Volume.17 No. 1 p.27 ~ p.33
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Impact of Oral Levonorgestrel for 1 Year on Mammographic Density in Menopausal Hormone Therapy
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Wee Chan-Woo
Kang Min-Jung
Seo Kyoung-Yong
Choe Yeon-Hyeon
Min Yong-Ki
Lee Dong-Yun
Choi Doo-Seok
Yoon Byung-Koo
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Abstract
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Objectives: We evaluated changes in mammographic density (MMGD) after hormone therapy (HT) using levonorgestrel (LNG) in Korean postmenopausal women.
Methods: In this retrospective study, 58 healthy postmenopausal women with no history of prior HT were included. Twenty-three women were given a cyclic regimen of estradiol valerate (E) 2 mg/day ＋ LNG 0.075 mg/day and 25 untreated women served as a negative control and 10 women treated with continuous combined regimen of conjugated equine estrogen (CEE) 0.625 mg/day ＋ medroxyprogesterone acetate (MPA) 2.5 mg/day as a positive control. Mammography was obtained at baseline and 1 year later, and MMGD was assessed. In addition, the change in the proportion of the dense area after HT was assessed using the J-image program. Data were analyzed with analysis of variance and chi-square or Fisher’s exact test.
Results: There were no significant differences in baseline characteristics among three groups. After 1 year of HT, increase of BI-RADS grade in CEE ＋ MPA group (7/9, 77.8%) was higher than in E ＋ LNG group (2/16, 12.5%; P = 0.001). But there was no difference between untreated group (1/19, 5.3%) and E ＋ LNG group (2/16, 12.5%; P = 0.446). In subgroup analysis of women with BI-RADS grade 3 at baseline, no significant difference. Changes in the proportion of dense areas assessed by the J-image program showed similar results. Regression analysis revealed that there was no correlation between baseline dense area and changes after HT in E ＋ LNG group.
Conclusion: HT using LNG did not influence MMGD in Korean postmenopausal women. Further study on breast cancer risk may be needed.
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KEYWORD
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Levonorgestrel, Mammographic density, Menopausal hormone therapy
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